Danger signals activating innate immunity in graft-versus-host disease

  title={Danger signals activating innate immunity in graft-versus-host disease},
  author={Robert Zeiser and Olaf Penack and Ernst Holler and Marco Idzko},
  journal={Journal of Molecular Medicine},
Extensive cell death with consecutive release of danger signals can cause immune-mediated tissue destruction. The abundance of cell death is likely to determine the relevance of the danger signals as physiological mechanisms that counteract immune activation may be overruled. Such constellation is conceivable in chemo-/radiotherapy-induced tissue damage, reperfusion injury, trauma, and severe infection. Studies on graft-versus-host disease (GvHD) development have to consider the effects of… CONTINUE READING
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Graft-versus-host disease enhanced by extracellular adenosine triphosphate activating P2X7R

  • K Wilhelm, J Ganesan, +7 authors E Jüttner
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