Danger-free autoimmune disease in Aire-deficient mice.

Abstract

The danger theory of immune tolerance asserts that environmental factors hold primacy over lymphocyte autoreactivity in initiating autoimmune disease. We sought to test this contention using the Aire-deficient mouse model of the human disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, a multiorgan autoimmune disorder rooted in a lesion… (More)

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@article{Strasser2007DangerfreeAD, title={Danger-free autoimmune disease in Aire-deficient mice.}, author={Andreas Strasser and Irina Catrinel Gavanescu and Christophe Benoist and Diane Mathis}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2007}, volume={104 46}, pages={18193-8} }