Danger-free autoimmune disease in Aire-deficient mice.


The danger theory of immune tolerance asserts that environmental factors hold primacy over lymphocyte autoreactivity in initiating autoimmune disease. We sought to test this contention using the Aire-deficient mouse model of the human disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, a multiorgan autoimmune disorder rooted in a lesion… (More)


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@article{Strasser2007DangerfreeAD, title={Danger-free autoimmune disease in Aire-deficient mice.}, author={Andreas Strasser and Irina Catrinel Gavanescu and Christophe Benoist and Diane Mathis}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2007}, volume={104 46}, pages={18193-8} }