Danger-associated molecular patterns (DAMPs) in acute lung injury.

  title={Danger-associated molecular patterns (DAMPs) in acute lung injury.},
  author={Leslie B Tolle and Theodore J Standiford},
  journal={The Journal of pathology},
  volume={229 2},
Danger-associated molecular patterns (DAMPs) are host-derived molecules that can function to regulate the activation of pathogen recognition receptors (PRRs). These molecules play a critical role in modulating the lung injury response. DAMPs originate from multiple sources, including injured and dying cells, the extracellular matrix, or exist as immunomodulatory proteins within the airspace and interstitium. DAMPs can function as either toll-like receptor (TLR) agonists or antagonists, and can… CONTINUE READING

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