Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

@article{Lefkowitz2002DancingWD,
  title={Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.},
  author={Robert J Lefkowitz and Kristen L. Pierce and Louis M Luttrell},
  journal={Molecular pharmacology},
  year={2002},
  volume={62 5},
  pages={971-4}
}
In simpler times, studies of G protein-coupled receptor (GPCR) signaling focused almost exclusively on pathways characterized by a small number of sequential events, largely confined to the plasma membrane [for example, activation of adenylyl cyclase by the 2AR (Lefkowitz, 2000)]. However, in recent years, there has been a growing awareness that GPCRs stimulate much more complex pathways that ultimately connect events at the plasma membrane to nuclear events, such as gene transcription… CONTINUE READING

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