The pivotal role of abscisic acid signaling during transition from seed maturation to germination
- BiologyPlant Cell Reports
Recent advances in ABA signaling pathway in the regulation of seed maturation as well as the transition from Seed maturation to germination are summarized, and the importance of system biology approaches in the study ofseed maturation is highlighted.
Close to the edge: co-authorship proximity of Nobel laureates in Physiology or Medicine, 1991–2010, to cross-disciplinary brokers
It is shown that the center of the biomedical sciences within the co-authorship graph of all of the sciences is closer to the edges of multiple non-biomedical disciplines than typical biomedical researchers are to each other.
Molecular mechanisms creating bistable switches at cell cycle transitions
- BiologyOpen Biology
A reaction motif is applied in detail to the G1/S transition in budding yeast and to the mitotic checkpoint in mammalian cells that provides a simple and generic account of many characteristic properties of cell cycle transitions.
Cell Culture as a Model
- Biology, Medicine
The sections in this article are: Historical Development of Cell Cultures for the Study of Aging, Relevance of in Vitro Cellular Senescence to in Vivo Aging, Mechanistic Studies of in vitro ReplicativeSenescence, and Caveats in the Use of Cellcultures as Models.
The plant cell cycle.
- Biology, MedicineAnnals of botany
Knowledge about genes that drive the cell cycle, and about hormones and their receptors that regulate development, is growing at an impressive pace. Such knowledge has accrued both before and during…
p53's Dilemma in Transcription: Analysis by Microarrays
The major conclusion is that the response to p53 activation is heterogeneous and is mainly dependent on the cellular context, which is evident from the pattern of p53-induced genes in different cell types and in various organs in response to irradiation.
A novel flexible framework with automatic feature correspondence optimization for nonrigid registration in radiotherapy.
- MedicineMedical physics
The authors concluded that the presented nonrigid registration framework is a powerful tool to simultaneously register multiple segmented organs with very different complexities.
CRK9 contributes to regulation of mitosis and cytokinesis in the procyclic form of Trypanosoma brucei
- Biology, MedicineBMC Cell Biology
CRK9 may play a role in mediating the segregation between the two kinetoplast/basal body pairs prior to cytokinetic initiation in the procyclic form of T. brucei.
Short Communication Expression of the G2-M Checkpoint Regulators Cyclin Bi and cdc2 in Nonmalignant and Malignant Human Breast Lesions Immunocytochemical and Quantitative Image Analyses
- Medicine, Biology
We investigated the in vivo expression of cyclin Bl and Cdc2 (key molecules for G2-M transition during the ceU cycle) in nonmalignant and cancerous buman breast lesions using immunobis-tocbemistry…
SHOWING 1-10 OF 21 REFERENCES
Negative regulation of FAR1 at the Start of the yeast cell cycle.
- BiologyGenes & development
It is found that FAR1 transcription and protein accumulation are regulated independently during the cell cycle, and that reaccumulation of Far1 protein to functional levels is restricted until after nuclear division.
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
The ubiquitin-conjugation system.
- BiologyAnnual review of genetics
The ubiquitin/proteasome system is believed to be the major nonlysosomal proteolytic system of eukaryotic cells and an important function of this pathway is the elimination of abnormal proteins generated under normal and, in particular, stress conditions.
WAF1, a potential mediator of p53 tumor suppression
An inhibitor of p34CDC28 protein kinase activity from Saccharomyces cerevisiae.
The p34CDC28 protein from Saccharomyces cerevisiae is a homolog of the p34cdc2 protein kinase, a fundamental regulator of cell division in all eukaryotic cells. Once activated it initiates the…
Checkpoints that couple gene expression to morphogenesis.
Radiosensitivity in ataxia-telangiectasia: a new explanation.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
Doses of x-radiation that markedly inhibited the rate of DNA synthesis in normal human cells caused almost no inhibition in AT cells and thus less delay during which x-ray damage could be repaired, allowing normal cells to repair DNA damage before it can be expressed.