Dampening Enthusiasm for Circulating MicroRNA in Breast Cancer

  title={Dampening Enthusiasm for Circulating MicroRNA in Breast Cancer},
  author={Rom S. Leidner and Li Li and Cheryl L. Thompson},
  booktitle={PloS one},
Genome-wide platforms for high-throughput profiling of circulating miRNA (oligoarray or miR-Seq) offer enormous promise for agnostic discovery of circulating miRNA biomarkers as a pathway for development in breast cancer detection. By harmonizing data from 15 previous reports, we found widespread inconsistencies across prior studies. Whether this arises from differences in study design, such as sample source or profiling platform, is unclear. As a reproducibility experiment, we generated a… CONTINUE READING