Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC‐A

@inproceedings{ElAjouz2017DampenedAO,
  title={Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC‐A},
  author={Sam El-Ajouz and Elisa Venturi and Katja Witschas and Matthew Beech and Abigail D Wilson and Chris Lindsay and David Eberhardt and Fiona O'Brien and Tsunaki Iida and Miyuki Nishi and Hiroshi Takeshima and Rebecca Sitsapesan},
  booktitle={The Journal of physiology},
  year={2017}
}
KEY POINTS The role of trimeric intracellular cation (TRIC) channels is not known, although evidence suggests they may regulate ryanodine receptors (RyR) via multiple mechanisms. We therefore investigated whether Tric-a gene knockout (KO) alters the single-channel function of skeletal RyR (RyR1). We find that RyR1 from Tric-a KO mice are more sensitive to inhibition by divalent cations, although they respond normally to cytosolic Ca2+ , ATP, caffeine and luminal Ca2+ . In the presence of Mg2… CONTINUE READING
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