Dammarane-type triterpenoids as 11β-HSD1 inhibitors from Homonoia riparia.

@article{Yu2014DammaranetypeTA,
  title={Dammarane-type triterpenoids as 11β-HSD1 inhibitors from Homonoia riparia.},
  author={Jinhai Yu and Yu Cindy Shen and Hong Liu and Ying Leng and Hua Bin Zhang and Jian-Min Yue},
  journal={Organic & biomolecular chemistry},
  year={2014},
  volume={12 26},
  pages={
          4716-22
        }
}
An exploration for 11β-HSD1 inhibitors from Homonoia riparia returned eight new dammarane-type triterpenoids, horipenoids A–H (1–8), and a known oleanane-type triterpenoid (9). Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data, and the absolute configuration of horipenoid E (5) was established by single crystal X-ray crystallography. Compounds 1–4 represent a rare class of octanortriterpenoids. Horipenoids C (3) and E (5) showed potent inhibition… CONTINUE READING

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