Damaging effects of cisplatin on mouse spermatozoa.

  title={Damaging effects of cisplatin on mouse spermatozoa.},
  author={Shigeru Oshio and Hiroshi Tomomasa and Hiroshi Amemiya and Takahito Yazaki and Hideo Mohri and Takuya Umeda and Masayuki Waku},
  journal={Archives of andrology},
  volume={24 2},
The effect of cis-diamminedichloroplatinum (cisplatin: CDDP) on mouse spermatozoa was evaluated quantitatively by means of equilibrium sedimentation in Percoll. CDDP was administered subcutaneously at doses of 1, 3, and 10 mg/kg/week for 5 weeks. After different periods (1, 3, and 10 weeks) without CDDP, the quality of epididymal sperm was evaluated by sperm count, motility, morphology of sperm, and the apparent density of sperm. At 10 mg/kg dose, about 80% mortality occurred during the… CONTINUE READING

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