Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair.

@article{Yeh2012DamagedDI,
  title={Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair.},
  author={Joanne I. Yeh and Arthur S. Levine and Shoucheng Du and Unmesh Chinte and Harshad Ghodke and Hong Wang and Haibin Shi and Ching L. Hsieh and James F. Conway and Bennett van Houten and Vesna Rapi{\'c}-Otrin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 41},
  pages={
          E2737-46
        }
}
  • Joanne I. Yeh, Arthur S. Levine, +8 authors Vesna Rapić-Otrin
  • Published in
    Proceedings of the National…
    2012
  • Biology, Medicine
  • UV light-induced photoproducts are recognized and removed by the nucleotide-excision repair (NER) pathway. In humans, the UV-damaged DNA-binding protein (UV-DDB) is part of a ubiquitin E3 ligase complex (DDB1-CUL4A(DDB2)) that initiates NER by recognizing damaged chromatin with concomitant ubiquitination of core histones at the lesion. We report the X-ray crystal structure of the human UV-DDB in a complex with damaged DNA and show that the N-terminal domain of DDB2 makes critical contacts with… CONTINUE READING

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