Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage

@inproceedings{Bagchi2010DamagedDNABP,
  title={Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage},
  author={Srilata Bagchi and Pradip Raychaudhuri},
  booktitle={Cell Division},
  year={2010}
}
Apoptosis induced by DNA damage is an important mechanism of tumor suppression and it is significant also in cancer chemotherapy. Mammalian cells activate the pathways of p53 to induce apoptosis of cells harboring irreparable DNA damages. While p53 induces expression of various pro-apoptotic genes and directly participates in the disruption of mitochondrial… CONTINUE READING