Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

@article{Hollander1995DamageTT,
  title={Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.},
  author={Anthony P Hollander and Isabelle Pidoux and Agnes T Reiner and Cecil H. Rorabeck and R. Gregory Bourne and A. Robin Poole},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 6},
  pages={2859-69}
}
Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, A.P., T.F. Heathfield, C. Webber, Y. Iwata, R. Bourne, C. Rorabeck, and A.R. Poole. 1994. J. Clin. Invest. 93:1722-1732). Using the same antibody that only reacts with denatured type II collagen, we investigated with immunoperoxidase histochemistry (results were graded for analysis) the sites of the denaturation (loss of triple helix… CONTINUE READING
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