Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.

Abstract

Enhanced denaturation of type II collagen fibrils in femoral condylar cartilage in osteoarthritis (OA) has recently been quantitated immunochemically (Hollander, A.P., T.F. Heathfield, C. Webber, Y. Iwata, R. Bourne, C. Rorabeck, and A.R. Poole. 1994. J. Clin. Invest. 93:1722-1732). Using the same antibody that only reacts with denatured type II collagen… (More)

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@article{Hollander1995DamageTT, title={Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.}, author={Anthony P Hollander and Isabelle Pidoux and Agnes Reiner and Cecil H Rorabeck and Robert B. Bourne and A. Robin Poole}, journal={The Journal of clinical investigation}, year={1995}, volume={96 6}, pages={2859-69} }