Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin.

@article{Ellison1988DamageOT,
  title={Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin.},
  author={Richard T. Ellison and Theodore Giehl and F Marc Laforce},
  journal={Infection and immunity},
  year={1988},
  volume={56 11},
  pages={2774-81}
}
Many studies have shown that lactoferrin and transferrin have antimicrobial activity against gram-negative bacteria, but a mechanism of action has not been defined. We hypothesized that the iron-binding proteins could affect the gram-negative outer membrane in a manner similar to that of the chelator EDTA. The ability of lactoferrin and transferrin to release radiolabeled lipopolysaccharide (LPS) from a UDP-galactose epimerase-deficient Escherichia coli mutant and from wild-type Salmonella… CONTINUE READING

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