Damage of the endothelial glycocalyx in chronic kidney disease.

  title={Damage of the endothelial glycocalyx in chronic kidney disease.},
  author={Jan-S{\"o}ren A Padberg and Anne Wiesinger and Giovana Seno di Marco and Stefan Reuter and Alexander Grabner and Dominik Kentrup and Alexander Lukasz and Hans Oberleithner and Hermann J. Pavenst{\"a}dt and Marcus Brand and Philipp K{\"u}mpers},
  volume={234 2},
BACKGROUND AND OBJECTIVES The endothelial glycocalyx (eGC), a mesh of anionic biopolymers covering the luminal surface of endothelial cells, is considered as an intravascular compartment that protects the vessel wall against pathogenic insults in cardiovascular disease. We hypothesized that chronic kidney disease (CKD) is associated with reduced eGC integrity and subsequent endothelial dysfunction. METHODS & RESULTS Shedding of two major components of the eGC, namely syndecan-1 (Syn-1) and… CONTINUE READING