Damage induced arrhythmias: mechanisms and implications.

  title={Damage induced arrhythmias: mechanisms and implications.},
  author={Hendrick E D J ter Keurs and Ying Ming Zhang and Allen W. Davidoff and Penelope A. Boyden and Yuji Wakayama and Misa Miura},
  journal={Canadian journal of physiology and pharmacology},
  volume={79 1},
Little is known about the role played by non-uniform myocardial stress and strain distributions and by non-uniform excitation contraction coupling in mechanisms underlying the premature beats that initiate an arrhythmia. We will review the evidence in support of a mechanism in which both non-uniform contraction and increased Ca2+ load of cells adjacent to acutely damaged cells are essential in the "spontaneous" generation of Ca2+ transients during the relaxation phase of the electrically driven… CONTINUE READING

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