Damage distribution and mutation spectrum: the case of 8-methoxypsoralen plus UVA in mammalian cells.

@article{Sage1991DamageDA,
  title={Damage distribution and mutation spectrum: the case of 8-methoxypsoralen plus UVA in mammalian cells.},
  author={Evelyne Sage and Anders C A Bredberg},
  journal={Mutation research},
  year={1991},
  volume={263 4},
  pages={217-22}
}
We determined the distribution of monoadducts and biadducts induced in the supF tRNA gene carried by the shuttle vector pZ189, after exposure to 8-methoxypsoralen (8-MOP) plus a double UVA (365 nm) irradiation. These data were compared to our previously published 8-MOP-photoinduced mutation spectrum obtained after propagation of the damaged shuttle vector in mammalian cells. One mutational hot spot in an ATAT/TATA sequence is targeted at a hot spot of biaddition. A second hot spot is not… CONTINUE READING

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