Damage control: Rorγt+ innate lymphoid cells in tissue regeneration.

  title={Damage control: Rorγt+ innate lymphoid cells in tissue regeneration.},
  author={Monica Romera-Hernandez and Patricia Aparicio-Domingo and Tom Cupedo},
  journal={Current opinion in immunology},
  volume={25 2},
Innate lymphoid cells (ILC) function at the crossroads of innate and adaptive immunity. ILC expressing Rorγt are involved in lymphoid organ formation during embryonic development and mucosal homeostasis and immunity after birth in both mice and man. Mucosal ILC can express natural cytotoxicity receptors NKp44 and NKp46 and produce IL-22, a cytokine pivotal in the control of epithelial innate defenses. The requirements for mouse Rorγt+ ILC development are well charted and in recent years factors… CONTINUE READING
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