Damage and regeneration of hair cell ciliary bundles in a fish ear following treatment with gentamicin

@article{Lombarte1993DamageAR,
  title={Damage and regeneration of hair cell ciliary bundles in a fish ear following treatment with gentamicin},
  author={Antoni Lombarte and Hong Young Yan and Arthur N. Popper and Janet S. Chang and Christopher Platt},
  journal={Hearing Research},
  year={1993},
  volume={64},
  pages={166-174}
}
Sensory hair cells in the striolar regions of the utricle and lagena of a teleost fish, the oscar (Astronotus ocellatus), were damaged following intramuscular injections of gentamicin sulfate. In order to determine whether fish can regenerate hair cells, the time course of damage and recovery was followed over a period of four weeks by scanning electron microscopy. Maximum loss of ciliary bundles occurred at about day 10 after the first of four daily injections of gentamicin (20 mg/kg) in 4-6… Expand
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  • Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1994
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Optimism is yielded that direct stimulation of hair cell production or transplantation of living hair cells may eventually become treatment modalities for the damaged human inner ear. Expand
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