Damage and regeneration of hair cell ciliary bundles in a fish ear following treatment with gentamicin

@article{Lombarte1993DamageAR,
  title={Damage and regeneration of hair cell ciliary bundles in a fish ear following treatment with gentamicin},
  author={Antoni Lombarte and Hong Young Yan and Arthur N. Popper and Janet S. Chang and Christopher Platt},
  journal={Hearing Research},
  year={1993},
  volume={64},
  pages={166-174}
}
View on Elsevier
doi.org
130 Citations
Highly Influential Citations
8
Background Citations
58
Methods Citations
2
Results Citations
1

130 Citations

Distribution and time course of hair cell regeneration in the pigeon utricle

Cell proliferation follows acoustically-induced hair cell bundle loss in the zebrafish saccule

Damage and recovery of hair cells in fish canal (but not superficial) neuromasts after gentamicin exposure

Sensory hair cell death and regeneration in fishes

TLDR
Advances derived from studies in zebrafish and other fish species include understanding the effect of ototoxins on hair cells and finding otoprotectants to mitigate ototoxin damage, and elucidating cellular pathways involved in the regeneration process.

A brief history of hair cell regeneration research and speculations on the future

Proliferative Regeneration of Zebrafish Lateral Line Hair Cells after Different Ototoxic Insults

Sensory hair cells in the zebrafish lateral line regenerate rapidly and completely after damage. Previous studies have used a variety of ototoxins to kill lateral line hair cells to study different…

Hair Cell Regeneration in the Inner Ear

  • E. RubelT. TsueE. OesterleE. Rubel
  • Medicine, Biology
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 1994
TLDR
Optimism is yielded that direct stimulation of hair cell production or transplantation of living hair cells may eventually become treatment modalities for the damaged human inner ear.

Apoptosis and hair cell degeneration in the vestibular sensory epithelia of the guinea pig following a gentamicin insult

Damage and functional recovery of the Atlantic cod (Gadus morhua) inner ear hair cells following local injection of gentamicin

TLDR
It is suggested that the macula sacculi of Atlantic cod can regenerate towards a near-complete functional and ultrastructural recovery within 17–21 days following ototoxic gentamicin treatment.

Two modes of hair cell loss from the vestibular sensory epithelia of the guinea pig inner ear

TLDR
Two distinct modes of hair cell loss were identified: degeneration of hair cells within the epithelium, which often showed morphological features consistent with those described for apoptosis, and extrusion of intact cells from the apical surface.
...

References

SHOWING 1-10 OF 28 REFERENCES

Light microscopic evidence of hair cell regeneration after gentamicin toxicity in chick cochlea.

TLDR
There appears to be a progressive partial recovery of the normal hair cell counts in the 25- and 32-day-old animals, whereas in the control chicks, there was a 36% hair cell loss.

Regeneration of hair cell stereociliary bundles in the chick cochlea following severe acoustic trauma

Hair Cell Loss and Regeneration after Exposure to Intense Sound in Neonatal Chicks

TLDR
Hair-cell restoration after severe acoustic injury from intense sound exposure in the neonatal ear is demonstrated and can be recognized by the disorganization of hair cells in the previously injured area.

Hair cell regeneration in the chicken cochlea following aminoglycoside toxicity

Hair cell damage and recovery following chronic application of kanamycin in the chick cochlea

Possible precursors of regenerated hair cells in the avian cochlea following acoustic trauma

Hair cell regeneration in the adult budgerigar after kanamycin ototoxicity

Ultrastructural observations on regenerating hair cells in the chick basilar papilla

Regeneration in the auditory system

Outer hair cell loss and supporting cell expansion following chronic gentamicin treatment