Damage-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing

  title={Damage-Induced Phosphorylation of Sld3 is Important to Block Late Origin Firing},
  author={Jaime Lopez-Mosqueda and Nancy L. Maas and Zophon{\'i}as Oddur J{\'o}nsson and Lisa G. DeFazio Eli and James A Wohlschlegel and David Paul Toczyski},
Origins of replication are activated throughout the S phase of the cell cycle such that some origins fire early and others fire late to ensure that each chromosome is completely replicated in a timely fashion. However, in response to DNA damage or replication fork stalling, eukaryotic cells block activation of unfired origins. Human cells derived from patients with ataxia telangiectasia are deficient in this process due to the lack of a functional ataxia telangiectasia mutated (ATM) kinase and… CONTINUE READING


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