Dam methylation: coordinating cellular processes.

  title={Dam methylation: coordinating cellular processes.},
  author={Anders L\obner-Olesen and Ole Skovgaard and M. G. Marinus},
  journal={Current opinion in microbiology},
  volume={8 2},
GATC sequences in Escherichia coli DNA are methylated at the adenine residue by DNA adenine methyltransferase (DamMT). These methylated residues and/or the level of DamMT can influence cellular functions such as gene transcription, DNA mismatch repair, initiation of chromosome replication and nucleoid structure. In certain bacteria, unlike E. coli, DamMT is essential for viability perhaps owing to its role in chromosome replication. DamMT has also been implicated as a virulence factor in… CONTINUE READING