Dam and its role in pathogenicity of Salmonella enterica.

  title={Dam and its role in pathogenicity of Salmonella enterica.},
  author={M{\'o}nica Nancy Giacomodonato and Sebasti{\'a}n Hern{\'a}n Sarnacki and Mari{\'a}ngeles Noto Llana and Mar{\'i}a Cristina Cerquetti},
  journal={Journal of infection in developing countries},
  volume={3 7},
Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in… CONTINUE READING

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N6-methyl-adenine: an epigenetic signal for DNA–protein interactions

Nature Reviews Microbiology • 2006
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