Daintain/AIF-1 (allograft inflammatory factor-1) promotes erythrocyte lysis and heme release probably via binding to hemoglobin.

Abstract

Free heme is potentially cytotoxic, particularly in the presence of oxidants or activated phagocytes. Daintain/AIF-1 (allograft inflammatory factor-1) is a macrophage factor that has been implicated in the regulation of inflammation. In the present study, daintain/AIF-1 was found to induce cytolysis of erythrocytes, resulting in heme release in vitro… (More)

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