Daily transdermal administration of selegiline to guinea-pigs preferentially inhibits monoamine oxidase activity in brain when compared with intestinal and hepatic tissues.

@article{Mawhinney2003DailyTA,
  title={Daily transdermal administration of selegiline to guinea-pigs preferentially inhibits monoamine oxidase activity in brain when compared with intestinal and hepatic tissues.},
  author={Michael G Mawhinney and Dennis Cole and Albert J. Azzaro},
  journal={The Journal of pharmacy and pharmacology},
  year={2003},
  volume={55 1},
  pages={27-34}
}
Selegiline has been formulated in an acrylic polymer adhesive mixture to be employed as a constant release topical patch for daily transdermal administration. Application of this selegiline transdermal system (STS) to guinea-pigs resulted in an average delivery of 1.185 mg selegiline/cm(2) patch/24 h. STS dose-response curves were generated by altering… CONTINUE READING