Daily rapid blood glucose variations may condition antithrombin III biologic activity but not its plasma concentration in insulin-dependent diabetes. A possible role for labile non-enzymatic glycation.

Abstract

The effect of rapid daily variation of glycemia and labile HbA1 on both antithrombin III (ATIII) activity and plasma concentration in ten insulin dependent diabetics has been evaluated. The variations of both plasma glucose and labile HbA1 were inversely correlated to the alterations of ATIII activity (r = -0.71 and r = -0.73, respectively, p less than 0.001), while no change in ATIII plasma concentration was present. These data suggest a direct role of glucose in determining rapid alteration of ATIII biologic activity, in vivo, in diabetes, probably mediated by labile non-enzymatic glycation.

Statistics

0200400600'89'92'95'98'01'04'07'10'13'16
Citations per Year

202 Citations

Semantic Scholar estimates that this publication has 202 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Ceriello1987DailyRB, title={Daily rapid blood glucose variations may condition antithrombin III biologic activity but not its plasma concentration in insulin-dependent diabetes. A possible role for labile non-enzymatic glycation.}, author={Antonio Ceriello and Dario Giugliano and Antonio Quatraro and Aldo Stante and Giorgio Consoli and Patrizia Dello Russo and F D'onofrio}, journal={Diabète & métabolisme}, year={1987}, volume={13 1}, pages={16-9} }