Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress.

@article{Bible2015DailyPP,
  title={Daily propranolol prevents prolonged mobilization of hematopoietic progenitor cells in a rat model of lung contusion, hemorrhagic shock, and chronic stress.},
  author={Letitia E. Bible and Latha V. Pasupuleti and Amy V. Gore and Ziad C. Sifri and Kolenkode B. Kannan and Alicia M. Mohr},
  journal={Surgery},
  year={2015},
  volume={158 3},
  pages={
          595-601
        }
}
INTRODUCTION Propranolol has been shown previously to decrease the mobilization of hematopoietic progenitor cells (HPCs) after acute injury in rodent models; however, this acute injury model does not reflect the prolonged period of critical illness after severe trauma. Using our novel lung contusion/hemorrhagic shock/chronic restraint stress model, we hypothesize that daily administration of propranolol will decrease prolonged mobilization of HPCs without worsening lung healing. METHODS Male… CONTINUE READING
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