Daily methylphenidate administration attenuates c-fos expression in the striatum of prepubertal rats.

@article{Chase2003DailyMA,
  title={Daily methylphenidate administration attenuates c-fos expression in the striatum of prepubertal rats.},
  author={Teena D Chase and Richard E Brown and Normand Carrey and Michael B Wilkinson},
  journal={Neuroreport},
  year={2003},
  volume={14 5},
  pages={769-72}
}
Methylphenidate (Ritalin) is a psychostimulant drug used to treat children with attention deficit hyperactivity disorder. Despite its widespread and increasing clinical use, little is known about the long-term consequences of drug treatment. We compared the effects of a single injection of methylphenidate with that of long-term methylphenidate injections (one/day; 14 days) on immediate-early gene expression (c-fos) in the striatum of prepubertal male rats. Rats (25 days old) were injected once… CONTINUE READING

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