Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins.

@article{Raap1999DailyIO,
  title={Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins.},
  author={Dani K Raap and Suzanne T Evans and Francisca Adilfa de Oliveira Garcia and Qiang Li and Nancy A. Muma and William A. Wolf and George Battaglia and Louis D van de Kar},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={288 1},
  pages={98-106}
}
The present studies examined the dose-response relationship of fluoxetine-induced desensitization of hypothalamic postsynaptic 5-HT1A receptors, as measured from the reduced neuroendocrine responses to a 5-HT1A agonist. Because hypothalamic Gz proteins mediate the ACTH and oxytocin responses to 5-HT1A receptor activation, we also determined the effect of fluoxetine on the levels of Gz proteins in the hypothalamus. Rats were injected daily for 14 days with saline or with fluoxetine doses of 0.3… CONTINUE READING
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