Daily dosing with flutamide or Casodex exerts maximal antiandrogenic activity.


OBJECTIVES Because the large increase in luteinizing hormone secretion induced by flutamide in the intact rat is not found in men, we have used castrated rats and mice supplemented with androstenedione (4-dione) instead of intact animals to measure the activity of the pure antiandrogens flutamide and Casodex. METHODS We first compared the effect of… (More)