Daily dosing prophylaxis for haemophilia: a randomized crossover pilot study evaluating feasibility and efficacy.

@article{Lindvall2012DailyDP,
  title={Daily dosing prophylaxis for haemophilia: a randomized crossover pilot study evaluating feasibility and efficacy.},
  author={Karin Lindvall and Jan Astermark and Sven Bj{\"o}rkman and Rolf C R Ljung and K Steen Carlsson and Sylvia Persson and E Berntorp},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  year={2012},
  volume={18 6},
  pages={855-9}
}
Regular replacement therapy (prophylaxis) for haemophilia has been shown to prevent development of disabling arthropathy and to provide a better quality of life compared to treatment on demand; however, at a substantially higher cost. Calculations based on pharmacokinetic principles have shown that shortening dose intervals may reduce cost. The aim of this prospective, randomized, crossover pilot study was to address whether daily dosing is feasible, if it reduces concentrate consumption and is… CONTINUE READING

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