Daily coordination of cancer growth and circadian clock gene expression

  title={Daily coordination of cancer growth and circadian clock gene expression},
  author={Shaojin You and Patricia A. Wood and Yin Xiong and Minoru Kobayashi and Jovelyn Du-Quiton and William J. M. Hrushesky},
  journal={Breast Cancer Research and Treatment},
Background.Circadian coordination in mammals is accomplished, in part, by coordinate, rhythmic expression of a series of circadian clock genes in the central clock within the suprachiasmatic nuclei (SCN) of the hypothalamus. These same genes are also rhythmically expressed each day within each peripheral tissue. Methods.We measured tumor size, tumor cell cyclin E protein, tumor cell mitotic index, and circadian clock gene expression in liver and tumor cells at six equispaced times of day in… CONTINUE READING


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Tumor cell circadian clock genes are rhythmically expressed in coordination with rhythmic circadian growth and thereby may represent new therapeutic targets

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