Daidzein promotes the expression of oxidative phosphorylation- and fatty acid oxidation-related genes via an estrogen-related receptor α pathway to decrease lipid accumulation in muscle cells.

@article{Kitamura2019DaidzeinPT,
  title={Daidzein promotes the expression of oxidative phosphorylation- and fatty acid oxidation-related genes via an estrogen-related receptor $\alpha$ pathway to decrease lipid accumulation in muscle cells.},
  author={Kanano Kitamura and Jane Surya Erlangga and Sakuka Tsukamoto and Yuri Sakamoto and Hideaki Mabashi-Asazuma and K. Iida},
  journal={The Journal of nutritional biochemistry},
  year={2019},
  volume={77},
  pages={
          108315
        }
}
Estrogen-related receptor (ERR)α regulates genes involved in fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) in muscle. The soy isoflavone daidzein was reported to be a putative ERRα activator, but little is known about its effects on gene expression and FA metabolism. This study aimed to clarify whether daidzein affects FAO- and OXPHOS-related genes thereby modulating intracellular FA metabolism in muscle cells. For this purpose, we used the C2C12 murine muscle cell line. ERR… Expand
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