Dactylorhin B reduces toxic effects of β-amyloid fragment (25–35) on neuron cells and isolated rat brain mitochondria

@article{Zhang2006DactylorhinBR,
  title={Dactylorhin B reduces toxic effects of β-amyloid fragment (25–35) on neuron cells and isolated rat brain mitochondria},
  author={Dan Zhang and Yi Zheng Zhang and Gengtao Liu and Jianjun Zhang},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2006},
  volume={374},
  pages={117-125}
}
β-amyloid is strongly implicated in Alzheimer’s pathology, and mitochondria play an important role in neurodegenerative disorders. Dactylorhin B [short for bis(4-β-D-glucopyranosyloxybenzyl)-2-β-D-glucopyranosyl-2-isobutyltartrate (DHB)] is an active compound isolated from Coeloglossum viride. (L.) Hartm. var. bracteatum (Willd.) and may have neuroprotective effects. In the present study, we investigated the damage of rat brain mitochondrial function induced by β-amyloid and the protective… CONTINUE READING

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