Dacarbazine as a minor groove binder of DNA: Spectroscopic, biophysical and molecular docking studies.

Abstract

A detailed investigation on the mode of action and binding mechanism of a potent anticancer drug, 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DCR) with calf thymus DNA (ctDNA) was carried out. UV-vis and fluorescence spectrophotometry suggested the formation of complex between DCR and ctDNA. The binding constant (Kb) determined by ITC was 7.89×10(4… (More)
DOI: 10.1016/j.ijbiomac.2015.04.055

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