Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy.

@article{Ahmed2015Dab2AN,
  title={Dab2, a negative regulator of DC immunogenicity, is an attractive molecular target for DC-based immunotherapy.},
  author={Md Selim Ahmed and Se Eun Byeon and Yideul Jeong and Mohammad Alam Miah and Md Salahuddin and Yoon Lee and Sung-Soo Park and Yong-Soo Bae},
  journal={Oncoimmunology},
  year={2015},
  volume={4 1},
  pages={e984550}
}
Dab2 is an adapter protein involved in receptor-mediated signaling, endocytosis, cell adhesion, hematopoietic cell differentiation, and angiogenesis. It plays a pivotal role in controlling cellular homeostasis. In the immune system, the Dab2 is a Foxp3 target gene and is required for regulatory T (Treg) cell function. Dab2 expression and its biological function in dendritic cells (DCs) have not been described. In this study, we found that Dab2 was significantly induced during the development of… CONTINUE READING
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