DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.

  title={DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia.},
  author={Olga Bogacheva and Oleg Bogachev and Madhu Menon and Arvind A. Dev and Estelle Houde and Elizabeth I Valoret and Haydn M. Prosser and Caretha L Creasy and Susan J Pickering and Evelyn V Grau and Kim H Rance and George P. Livi and Vinit Karur and Connie L. Erickson-Miller and Don M. Wojchowski},
  journal={The Journal of biological chemistry},
  volume={283 52},
During anemia erythropoiesis is bolstered by several factors including KIT ligand, oncostatin-M, glucocorticoids, and erythropoietin. Less is understood concerning factors that limit this process. Experiments performed using dual-specificity tyrosine-regulated kinase-3 (DYRK3) knock-out and transgenic mice reveal that erythropoiesis is attenuated selectively during anemia. DYRK3 is restricted to erythroid progenitor cells and testes. DYRK3-/- mice exhibited essentially normal hematological… CONTINUE READING