DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.

@article{Taira2012DYRK2PP,
  title={DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.},
  author={N. Taira and R. Mimoto and M. Kurata and Tomoko Yamaguchi and M. Kitagawa and Y. Miki and K. Yoshida},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 3},
  pages={
          859-72
        }
}
Dysregulation of the G(1)/S transition in the cell cycle contributes to tumor development. The oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this transition, and their aberrant expression is associated with many malignancies. Degradation of c-Jun/c-Myc is a critical process for the G(1)/S transition, which is initiated upon phosphorylation by glycogen synthase kinase 3 β (GSK3β). However, a specific kinase or kinases responsible for priming phosphorylation… Expand
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