DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.

@article{Mimoto2013DYRK2CT,
  title={DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail.},
  author={Rei Mimoto and Naoe Taira and Hiroyuki Takahashi and Tomoko Yamaguchi and Masataka Okabe and K. Uchida and Yoshio Miki and Kiyotsugu Yoshida},
  journal={Cancer letters},
  year={2013},
  volume={339 2},
  pages={214-25}
}
The epithelial-mesenchymal transition (EMT) plays a fundamental role in the early stages of breast cancer invasion. Snail, a zinc finger transcriptional repressor, is an important regulator of EMT. Snail is phosphorylated by GSK3β and is subsequently degraded by βTrCP-mediated ubiquitination. We identified an additional kinase, DYRK2, that regulates Snail stability. Knockdown of DYRK2 promoted EMT and cancer invasion in vitro and in vivo. Consistent with these results, DYRK2 was found to be… CONTINUE READING

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