DYRK1A: a potential drug target for multiple Down syndrome neuropathologies.

@article{Becker2014DYRK1AAP,
  title={DYRK1A: a potential drug target for multiple Down syndrome neuropathologies.},
  author={Walter Becker and Ulf Soppa and Francisco J Tejedor},
  journal={CNS & neurological disorders drug targets},
  year={2014},
  volume={13 1},
  pages={26-33}
}
Down syndrome (DS), the most common genetic cause of intellectual disability, is caused by the trisomy of chromosome 21. MNB/DYRK1A (Minibrain/dual specificity tyrosine phosphorylation-regulated kinase 1A) has possibly been the most extensively studied chromosome 21 gene during the last decade due to the remarkable correlation of its functions in the brain with important DS neuropathologies, such as neuronal deficits, dendrite atrophy, spine dysgenesis, precocious Alzheimer's-like… CONTINUE READING