DY-9760e, a novel calmodulin antagonist, reduces brain damage induced by transient focal cerebral ischemia.

@article{Sato1999DY9760eAN,
  title={DY-9760e, a novel calmodulin antagonist, reduces brain damage induced by transient focal cerebral ischemia.},
  author={Toshiyuki Sato and Yoshiyuki Morishima and Masunobu Sugimura and Takahiro Uchida and Yasufumi Shirasaki},
  journal={European journal of pharmacology},
  year={1999},
  volume={370 2},
  pages={117-23}
}
Perturbations in Ca2+ homeostasis have been proposed to lead to neuronal damage after cerebral ischemia. DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylethyl)-1H-indazole dihydrochloride 3.5 hydrate) is a novel calmodulin antagonist. In this study, we examined the effects of DY-9760e on brain damage in rats subjected to transient (1 h) focal cerebral ischemia. DY-9760e (0.25-1.00 mg kg(-1) h(-1)) was intravenously infused for 6 h, starting 1 h… CONTINUE READING

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