DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria

  title={DW-F5: A novel formulation against malignant melanoma from Wrightia tinctoria},
  author={Jayesh Antony and Minakshi Saikia and V Vinod. and Lekshmi. R. Nath and Mohana Rao Katiki and M. C. Kesava Murty and Anju Paul and A Shabna and Harsha Chandran and Sophia Margaret Joseph and S NishanthKumar. and Elizabeth Jayex Panakkal and V SriramyaI. and V SridivyaI. and Sophia Ran and S Sankar and Easwary Rajan and Ruby John Anto},
  booktitle={Scientific reports},
Wrightia tinctoria is a constituent of several ayurvedic preparations against skin disorders including psoriasis and herpes, though not yet has been explored for anticancer potential. Herein, for the first time, we report the significant anticancer properties of a semi-purified fraction, DW-F5, from the dichloromethane extract of W. tinctoria leaves against malignant melanoma. DW-F5 exhibited anti-melanoma activities, preventing metastasis and angiogenesis in NOD-SCID mice, while being non… CONTINUE READING

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