DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy.


Facioscapulohumeral dystrophy (FSHD) is one of the most common inherited muscular dystrophies. The causative gene remains controversial and the mechanism of pathophysiology unknown. Here we identify genes associated with germline and early stem cell development as targets of the DUX4 transcription factor, a leading candidate gene for FSHD. The genes… (More)
DOI: 10.1016/j.devcel.2011.11.013


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