DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.

@article{Liu2016DUSP8RC,
  title={DUSP8 Regulates Cardiac Ventricular Remodeling by Altering ERK1/2 Signaling.},
  author={Ruijie Liu and Jop H van Berlo and Allen J. York and Ronald J. Vagnozzi and Marjorie Maillet and Jeffery D Molkentin},
  journal={Circulation research},
  year={2016},
  volume={119 2},
  pages={
          249-60
        }
}
RATIONALE Mitogen-activated protein kinase (MAPK) signaling regulates the growth response of the adult myocardium in response to increased cardiac workload or pathological insults. The dual-specificity phosphatases (DUSPs) are critical effectors, which dephosphorylate the MAPKs to control the basal tone, amplitude, and duration of MAPK signaling. OBJECTIVE To examine DUSP8 as a regulator of MAPK signaling in the heart and its impact on ventricular and cardiac myocyte growth dynamics… CONTINUE READING
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