DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.

@article{Patterson2010DUSP26NA,
  title={DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs.},
  author={Kate I Patterson and Tilman Brummer and Roger J. Daly and Philippa M. O'Brien},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1803 9},
  pages={1003-12}
}
Dual specificity phosphatases are characterised by their ability to dephosphorylate both phosphotyrosine and phosphoserine/threonine residues within the one substrate. The aim of this study was to characterise the phosphatase activity of the atypical dual specificity phosphatase, DUSP26 on MAP kinases, and to determine its expression, regulation and function in cancer cells. Overexpression and knockdown of DUSP26 in epithelial cells and in vitro phosphatase assays were used to demonstrate that… CONTINUE READING
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