DUFs: families in search of function

@inproceedings{Bateman2010DUFsFI,
  title={DUFs: families in search of function},
  author={Alex Bateman and Penny C. Coggill and Robert D. Finn},
  booktitle={Acta crystallographica. Section F, Structural biology and crystallization communications},
  year={2010}
}
Domains of unknown function (DUFs) are a large set of uncharacterized protein families that are found in the Pfam database. Here, the scale and growth of functionally uncharacterized families in biological databases are surveyed and the prospects for discovering their function are examined. In particular, the important role that structural genomics can play in identifying potential function is evaluated. 
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