DUBs, the regulation of cell identity and disease.

@article{Heideker2015DUBsTR,
  title={DUBs, the regulation of cell identity and disease.},
  author={Johanna Heideker and Ingrid E. Wertz},
  journal={The Biochemical journal},
  year={2015},
  volume={465 1},
  pages={
          1-26
        }
}
The post-translational modification of proteins with ubiquitin represents a complex signalling system that co-ordinates essential cellular functions, including proteolysis, DNA repair, receptor signalling and cell communication. DUBs (deubiquitinases), the enzymes that disassemble ubiquitin chains and remove ubiquitin from proteins, are central to this system. Reflecting the complexity and versatility of ubiquitin signalling, DUB activity is controlled in multiple ways. Although several lines… CONTINUE READING

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