DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.

@article{Alimirah2006DU145AP,
  title={DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation.},
  author={Fatouma Alimirah and Jianming Chen and Zane Basrawala and Hong Xin and Divaker Choubey},
  journal={FEBS letters},
  year={2006},
  volume={580 9},
  pages={2294-300}
}
The majority of human prostate cancer cell lines, including the two "classical" cell lines DU-145 and PC-3, are reported to be androgen receptor (AR)-negative. However, other studies have provided evidence that the DU-145 and PC-3 cell lines express AR mRNA. These contradictory observations prompted us to investigate whether DU-145 and PC-3 cell lines express the androgen receptor. Using antipeptide antibodies directed against three distinct regions of the human AR protein and an improved… CONTINUE READING

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