DTI correlates of cognition in term children with spastic diplegic cerebral palsy.

@article{Rai2013DTICO,
  title={DTI correlates of cognition in term children with spastic diplegic cerebral palsy.},
  author={Yogita Rai and Saurabh Chaturvedi and Vimal Kumar Paliwal and Puneet Goyal and Ankita Chourasia and Ram Kishore Singh Rathore and Abhishek Yadav and Chandra Mani Pandey and Rakesh Lalla and Ravindra Kumar Garg and Rakesh K. Gupta},
  journal={European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society},
  year={2013},
  volume={17 3},
  pages={
          294-301
        }
}
  • Y. Rai, Saurabh Chaturvedi, +8 authors Rakesh K. Gupta
  • Published 1 May 2013
  • Psychology, Medicine
  • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
BACKGROUND AND AIMS Presently, there is no published study that shows association between cognition and white matter injury in spastic cerebral palsy. We aimed to correlate cognitive functions with diffusion tensor imaging derived metrics in spastic diplegic children. METHODS Twenty-two term children with spastic diplegia and 22 healthy controls were recruited. All patients were graded on the basis of gross motor function. The Indian children intelligence Test was used to quantify cognition… 
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References

SHOWING 1-10 OF 55 REFERENCES
MRI features of cerebral lesions and cognitive functions in preterm spastic diplegic children.
TLDR
In spastic diplegic children, an MRI examination between the ages of 1 and 2 years may be helpful in predicting a specific neuropsychological pattern of dysfunction and in defining an early intervention program.
Treatment-induced plasticity in cerebral palsy: a diffusion tensor imaging study.
TLDR
The increase in fractional anisotropy in corticospinal tracts, along with improved clinical motor scores, suggests plasticity of the central motor pathway after combined therapy.
Correlation of quantitative sensorimotor tractography with clinical grade of cerebral palsy
TLDR
White matter tracts from both the somatosensory and the motor cortex play an important role in the pathophysiology of motor disability in patients with CP, and significant inverse correlation between clinical grade and fractional anisotropy was observed.
Comparing quantitative tractography metrics of motor and sensory pathways in children with periventricular leukomalacia and different levels of gross motor function
TLDR
Children with bilateral spastic CP with differing levels of gross motor function have corresponding differences detectable on DTT in their corticospinal tracts but not in their somatosensory tracts and posterior thalamic radiations.
Diffusion Tensor Imaging in Children with Periventricular Leukomalacia: Variability of Injuries to White Matter Tracts
TLDR
The tract-specific evaluation of diffusion tensor imaging revealed a family of tracts that are highly susceptible in PVL, important information that can potentially be used to tailor treatment options in the future.
Cognitive Profiles and Visuoperceptual Abilities in Preterm and Term Spastic Diplegic Children With Periventricular Leukomalacia
TLDR
The authors conclude that the management of preterm and term children should differ, with concentration on visuoperceptual skills and rehabilitation in the former.
Cognitive functions correlate with white matter architecture in a normal pediatric population: A diffusion tensor MRI study
TLDR
The results of DTI are consistent with the hypothesis that regionally specific increased fiber organization is a mechanism responsible for the normal development of white matter tracts.
Brain lesions in preterms: origin, consequences and compensation
TLDR
High‐risk preterm born children, from a cohort with cerebral blood flow measurements in the first 2 d of life, were examined prospectively at the age of 5.5—7 y neurologically, neuropsychologically and by magnetic resonance imaging (MRI), showing specific morphological correlates for the major disabilities.
White Matter Injury Correlates with Hypertonia in an Animal Model of Cerebral Palsy
  • A. Drobyshevsky, M. Derrick, +6 authors Sidhartha Tan
  • Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2007
TLDR
Hypertonia is associated with white matter injury, and a population of hypertonia can be identified by magnetic resonance imaging variables because the dynamic response of FA may be a good indicator of the plasticity and repair of the postnatal developing brain.
Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment.
TLDR
Though treated early, patients with chronic, stable malignant PKU had abnormal DT findings in the parieto-occipital central white matter, suggesting EV2, EV3, and FA maps are potential tools for demonstrating brain changes due to malignantPKU.
...
1
2
3
4
5
...