DSS1 is required for the stability of BRCA2

  title={DSS1 is required for the stability of BRCA2},
  author={Jun Li and C Zou and Yun-qing Bai and David E. Wazer and Vimla Band and Qian Gao},
DSS1 is an evolutionarily conserved acidic protein that binds to BRCA2. However, study of the function of DSS1 in mammalian cells has been hampered because endogenous DSS1 has not been detectable by Western blotting. Here, we developed a modified Western blotting protocol that detects endogenous DSS1 protein, and used it to study the function of DSS1 and its interaction with BRCA2 in mammalian cells. We found that essentially all BRCA2 in human cell lines is associated with DSS1. Importantly… CONTINUE READING


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