DSP4-induced two-way active avoidance impairment in rats: Involvement of central and not peripheral noradrenaline depletion

@article{Archer1982DSP4inducedTA,
  title={DSP4-induced two-way active avoidance impairment in rats: Involvement of central and not peripheral noradrenaline depletion},
  author={Trevor Archer and Sven Ove {\"O}gren and G{\"o}ran Johansson and Svante B. Ross},
  journal={Psychopharmacology},
  year={1982},
  volume={76},
  pages={303-309}
}
N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) (50 mg/kg IP), a new selective noradrenaline (NA) neurotoxin, was found to cause a severe impairment of the acquisition of a two-way active avoidance task 1 week following adminsitration, an effect that was blocked by the selective NA uptake inhibitor desipramine. In a second experiment, systemically injected 6-OHDA (2×30 mg/kg IP) was not found to cause any avoidance impairment, althogh its effects upon peripheral NA were still evident 21 days… CONTINUE READING
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Long-term effect of N-2-chloroethyl-N-ethyl-2-bromobenzylamine hydrochloride on noradrenergic neurons in the rat brain and heart

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1981a) N-2-Chloroet@l-N-ethyl-2bromobenzylamine hydrochloride (DSP4), a new selective noradrenaline neurotoxin, and taste neophobia in the rat

  • T Archer, SO s, SB Ross
  • Physiol Psychol
  • 1981

DSP4, a selective noradrenaline neurotoxin, and avoidance learning in the rat

  • T Archer, SO Ogren, SB Ross, G Johansson
  • 1981

Glucocorticoids, catecholamines and avoidance learning

  • SO Jgren, T Archer, K Fuxe, P Eneroth
  • Pergamon, Oxford New York,
  • 1981

Evidence for a role of the locus coeruleus noradrenaline system in learning

  • SO s, T Archer, SB Ross
  • Neurosci Lett
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